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SCIENTIFIC-PRACTICAL PEER-REVIEWED MONTHLY JOURNAL.
INSTITUTION OF MINISTRY OF PUBLIC HEALTH OF THE REPUBLIC OF BELARUS

SLEEP STRUCTURE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

Objective. To determine the sleep structure features in patients with type 1 diabetes (DM1). To establish differences in the somnological indicators depending on the glycated hemoglobin (HbA1c) value.

Materials and methods. 114 persons with DM1 were examined. Group 1 consisted of 79 person with DM1, 35 healthy persons were included into group 2 (control). During the study, every subject was assayed for the HbA1c level and was exposed to the polysomnographic (PSG) monitoring. All patients with DM1 were divided into 2 subgroups: 1a included patients with HbA1c £7.0% and 1b — those having HbA1с ³7.0%.

Results. The most prolonged sleep was recorded in case of compensated DM1 — 5.7 hours vs 4.8 hours (p=0.0205). Deficiency of the N3 fraction in subgroup 1a was 4.2% in case of compensated DM1 and 2.9% when DM1 was decompensated (p=0.0158, p <0.0001). In comparison with the control values, the N4 stage duration was 3.1 times less in case of the compensated DM1 and 6.6 times less in the patients with the decompensated DM1. During sleep, the patients with HbA1c ³7% woke up more often and had the longest intervals of wakefulness during sleep.

Conclusion. Patients with for DM1 demonstrated shorter night sleep and deficiency of the sleep deep NREM stages. PSG signs of insomnia disorders were recorded.