Short QT syndrome: diagnostic criteria
Objective. To estimate the short-term results, radiotoxicity, and economic efficiency of the conventional postoperative radiotherapy and the intensity modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) during hypofractionating regimen for early breast cancer (T1N0M0, T2N0M0).
Materials and methods. Methods of early breast cancer radiotherapy after breast-conserving surgery and chemotherapy were developed and introduced in the clinical practice. 160 patients with stage I-II breast carcinoma were randomized for IV groups up to 40 patients. The experimental groups involved 120 women with I—IIA stage carcinoma performed the total breast and the tumor bed polychemotherapy after the organ preserving operation (lumpectomy with axillary lymph nodes dissection) - Group 1. Group 2 included patients carried out hypofractionated partial-breast intensity-modulated radiotherapy with simultaneous integrated boost. The hypofractionated partial-breast irradiation by brachytherapy was carried out in Group 3. Women of the control group (n=40) received the conventional three-dimensional conformal radiation therapy. The acute and late toxicity of skins, lungs and hearts were studied. The short-term results, economic efficiency of various radiotherapy techniques are determined, too.
Results. The data were analyzed. The decreasing of frequency and degree of acute and late toxicity of skins, lungs, hearts as well as a sixfold reduction of the total time of irradiation and hospitalization days were achieved thanks to the developed methods of postoperative radiotherapy of patients with early breast cancer. A significant economic benefit the treatment efficiency preserved was established when comparing with the standard fractionating radiotherapy results.
Conclusion. The developed methods of radiotherapy with hypofractionation have allowed to receive good results of treatment and to retain quality of a life of patients at the expense of earlier achievement of the women medical, social, and family rehabilitation.