Potential donor hormone replacement therapy and donor organs pharmacological protection at explantation stage
Objective. To evaluate the effectiveness of the hormone replacement (HRT) scheme developed for a potential donor (PD) and of the organs pharmacological protection at the explantation stage followed by assessment of the graft function in the early postoperative period.
Materials and methods. A randomized, prospective, single-centered study was conducted aiming at determining the effectiveness of the HRT scheme proposed (methylprednisolone, levothyroxine, insulin, metformin, desmopressin) at the stage of the PD conditioning with the pharmacological agents: heparin, streptokinase, ebrantil during the explantation stage with 80 potential donors with brain death involved and analyzing the results of 144 kidney transplantations.
Results. The need in vasopressors was statistically proved to reduce at the donor stage, the basal metabolism and the heat production to enhance in all the patients treated with HRT when PD conditioning on the donor phase. The pharmacological protection use improves the metabolic and the effluent electrolyte performance after the donor's kidney flushing. The number of multiorgan donor retrievals and the transplanted kidney primary functioning increased reliably compared to the control group.
Conclusion. The HTR use and the donor's organs pharmacological protection suggested by the authors improves the quality of potential donors conditioning during a kidney transplantation.