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SCIENTIFIC-PRACTICAL PEER-REVIEWED MONTHLY JOURNAL.
INSTITUTION OF MINISTRY OF PUBLIC HEALTH OF THE REPUBLIC OF BELARUS

MATRIX METALLOPROTEINASE-14 AS MARKER FOR PERIODONTITIS CHRONIC COURSE

 

Objective. To determine the matrix metalloproteinase-14 (MMP-14) expression patterns in aggressive and in chronic periodontitis.

Materials and methods. The study was performed on the material of the gingival biopsies from 30 patients with periodontitis including 13 patients with aggressive periodontitis and 17 patients with chronic periodontitis: among them 12 subjects had simple periodontitis and 5 — complicated one. The expression intensity was assessed using histological slides stained by immunohistochemistry with antibodies to MMP-14.

Results. The chronicity of the disease was found to be associated with the enzyme strong expression in the gingival stroma.

Conclusion. Strong MMP-14 expression was observed in the chronic periodontitis but not in the aggressive periodontitis. Thus, MMP-14 can be used as a marker of the chronic process making possible the disease form determination and the course prediction as well as the therapeutic tactics selection.