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SCIENTIFIC-PRACTICAL PEER-REVIEWED MONTHLY JOURNAL.
INSTITUTION OF MINISTRY OF PUBLIC HEALTH OF THE REPUBLIC OF BELARUS

LONG-TERM RESULTS OF COMBINED THERAPY FOR LOCALLY ADVANCED PROSTATE CANCER

 

Objective. To evaluate the results of treating patients with stage III—IV prostate cancer without distant metastases using the developed scheme of polychemotherapy, 3D-conformal radiation therapy (RT), and long-term androgen deprivation.

Materials and methods. The randomized study included 91 patients with prostate cancer cT3a-4pN0-1M0 treated in 2006 to 2010 at N. N. Alexandrov National Cancer Centre of Belarus. Each patient of the main group additionally received polychemotherapy with «docetaxel + vinorelbine» on the background of radiotherapy, in the control group radiation and hormonal treatment was performed.

Results. The additional use of polychemotherapy with «docetaxel + vinorelbine» in patients with an unfavorable prognosis (pN1) allows a statistically significant increase of the 7-years cancer-specific survival by 23.3% in comparison with the course of HT+RT: the cancer-specific survival values in the main and control groups were 75.6±9.6 and 52.3±12.5, respectively (median — 88.6 months) (p=0.044).

Authors: S. L. Polyakov