Immune status of children with bronchial asthma
Objective. То study the immune status indices of children with bronchial asthma in different age groups.
Materials and methods. The study included 116 children with atopic bronchial asthma aged 5 to 18 years. The first group included 61 children aged 6 to 11 years and the second group consisted of 55 patients aged 12 to 18years. The levels of CD3+, CD4+, CD4+CD25+ T-lymphocytes, CD19+, CD19+CD23++ B-lymphocytes, CD203c+, CD203c+CD63+, CD203c+lgE+ basophils, of eosinophils as well as of eosinophils bearing the FceRl+ receptor were studied.
Results. The study has identified that the absolute levels of CD3+ and CD4+ T-lymphocytes are significantly higher in children of the younger age group (P1-2 <0.01). The relative levels of CD4+ and CD4+CD25+ T-lymphocytes are statistically reliably higher in the older age group (P1-2<0.05). The absolute level of CD19+ B-lymphocytes is statistically higher in young children (P1-2<0.01), compared with the level in older patients. Patients of both the younger and older age groups have high levels of basophils bearing CD203c+CD63+ and CD203c+lgE+ receptors significantly exceeding the reference values but no significant differences have been found between the groups. The relative and the absolute contents of eosinophils is statistically significantly higher in children aged 6 to 11 years (P1_2<0.01).
Conclusion. The data obtained during the study testify to the age associated features of the immune status in children with bronchial asthma.