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SCIENTIFIC-PRACTICAL PEER-REVIEWED MONTHLY JOURNAL.
INSTITUTION OF MINISTRY OF PUBLIC HEALTH OF THE REPUBLIC OF BELARUS

COMPARATIVE ANALYSIS OF METHODS ESTIMATING RENAL FUNCTION IN PATIENTS WITH GOUTY ARTHRITIS

Objective. In clinical practice for the renal function estimation and the CKD definition we routinely used Reberg—Tareev test as the reference method and the glomerular filtration rate (GFR) and the clearance creatinine (ClCr) estimating equations such as MDRD, CKD-EPI and Cockroft—Gault (CG).

Materials and methods. We compared the performance of MDRD, CKD-EPI, CG equations in 75 patients with gouty arthritis frequently suffering from advanced CKD. GFR using urinary and plasma concentrations of creatinine (Reberg—Tareev method) was performed as the reference test. The subgroups for analysis were defined by the GFR, sex, age, body mass index (BMI), diabetes status, and plasma creatinine values. The studied methods prognostic value was studied.

Results. When we used the CG equation the number of patients with CKD III decreased (р=0,021). The eGFR/eClCr average means of the analyzing methods according to the CKD classification did not differ from the reference test values. We found no difference between the eGFR/eClCr and the reference test values in patients with BMI less than 30 kg/мІ. The CKD-EPI equation was accurate in the most subgroups. The prognostic coefficient was higher in using the MDRD и CKD-EPI equations.

Conclusion. In patients with gouty arthritis the CKD-EPI equation and, a bit rarer, the MDRD equation are more accurate and may be preferable as the first tests for evaluating the renal function.