COMPARATIVE ANALYSIS OF CARBOHYDRATE METABOLISM INDICES, VASCULAR ENDOTHELIUM FUNCTION AND LIPID SPECTRUM IN PATIENTS WITH CORONARY HEART DISEASE COMBINED WITH DIABETES MELLITUS TYPE 2
Objective. To compare laboratory indices, to detect relationships between the carbohydrate metabolism parameters, the indices characterizing the vascular endothelium function and the lipid spectrum in patients with coronary heart disease and concomitant diabetes mellitus type 2 (DM type 2).
Materials and methods. 150 patients who were treated in SI «RRC for RM&HE» with the verified compensated, subcompensated or decompensated DM type 2 and the verified coronary heart disease: stable angina of tension of functional class II—III (CHD: SA of tension FC II-III) were included in the study and formed the major group. The control group consisted of 30 healthy patients. The persons examined were comparable by the age (p=0.263), coronary disease duration (p=0.081), DM type 2 duration (p=0.479), the disease course, and the management tactics.
Results. A comparative assessment of the laboratory indices, the relationships between the carbohydrate metabolism parameters, the indices characterizing the vascular endothelium function, the lipid spectrum in the patients with CHD and concomitant DM type 2 was performed.
Conclusion. It was found that the laboratory parameters changes in coronary heart disease at the background of diabetes mellitus were more pronounced and were characterized by the glycated hemoglobin high content being significantly higher in the group of patients with CHD combined with DM type 2 than in other groups (p<0.001, p=0.019, respectively), by a significant imbalance between the vasodilating and vasoconstrictor factors, by the TH, CT, LDL, AI increased levels, by the HDL decreased level, as well as by an imbalance of the LDL and HDL atherogenic and antiatherogenic fractions. Significant relationships between the vascular endothelial function indices and the HbA1c, % and VLDL values, the lipid metabolism (VLDL, HDL) and HbA1c, % have been determined. The finding may serve a confirmation of their complex effect on the development and progression of the atherosclerotic process in this category of patients.