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SCIENTIFIC-PRACTICAL PEER-REVIEWED MONTHLY JOURNAL.
INSTITUTION OF MINISTRY OF PUBLIC HEALTH OF THE REPUBLIC OF BELARUS

BLOOD OXYGEN CARRYING FUNCTION AND ACTIVITY OF FREE RADICAL PROCESSES IN CASE OF PULMONARY TUBERCULOSIS DIFFERENT CLINICAL FORMS

Objective. Studying the indicators of the blood oxygen carrying function and the activity of the free radical processes in the pulmonary tuberculosis different clinical forms.

Materials and methods. One hundred and twenty patients with pulmonary tuberculosis different clinical forms were examined and their venous blood oxygen carrying function and the free radical processes activity were studied.

Results. The most pronounced deterioration in the blood oxygen carrying function occurred in case of disseminated tuberculosis and the minimal one in case of the pulmonary tuberculosis small forms. The nitrate/nitrite concentration increase was found to increase to the highest level in case of disseminated forms. Tuberculosis caused an oxidative stress development increasing depending on the tuberculosis process spread and the patient’s condition severity. The highest activity of the free radical processes was observed in case of the disseminated tuberculosis and a less pronounced was revealed in case the pulmonary tuberculosis small forms.

Conclusion. Patients with the pulmonary tuberculosis different clinical forms demonstrate a shift of the oxyhemoglobin dissociation curve to the right. The increase identified in the examined patients’ plasma nitrate/nitrite contents can be important for changing the blood oxygen carrying function and the free radical processes activity case of the tuberculosis forms studied.