Objective. To investigate the placental blood circulation in the maternal-placental blood system and in the fetoplacental system in women with chronic venous insufficiency. Materials and methods. We assessed parameters of Doppler velocimetry of umbilical and uterine arteries in a group of women with chronic venous disease (n=52). Healthy pregnant women made the control group (n=21).
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BLOOD SERUM FUCOSE AS PREDICTIVE FACTOR OF PROGRESSING LIVER FIBROSIS AND POTENTIAL MARKER OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HCV INFECTION
The results of the determination of total fucose in blood serum in groups of practically healthy persons and patients with various forms of HCV infection are presented. The possibility of using the fucose concentration as an indicator of progressive liver fibrosis in patients with chronic HCV infection is demonstrated. The optimal value of blood fucose is established allowing presume the hepatocellular carcinoma development in patients with HCV-associated cirrhosis.
PREPARATION AND DESCRIPTION OF RECOMBINANT POLYPEPTIDES REPRESENTING ANTIGENICALLY ACTIVE REGIONS OF HANTAVIRUS NUCLEOCAPSID PROTEINS
Objective. Preparation of highly purified recombinant polypeptides representing antigenically active regions of hantavirus nucleocapsid proteins Puumala, Kurkino, Hantaan and studying of their antigenic specificity.
Objective. To simulate a model of acute necrotizing pancreatitis (SNPS) in rats reproducing the processes occurring in the body of a sick person. Materials and methods. To simulate a model of SNPS we used 16 individuals of SD rats of the categories SPF at the age of 12—14 weeks. They were divided into 4 groups four animals in each.
Objective. To develop an algorithm of carrying out stress tests at patients with valvular heart diseases. Materials and methods. 62 patients with the chronic rheumatic heart disease including 42 (68%) women and 20 (32%) men aged 36 to 67 (average age 53.3±8.8 years) were examined.
PROGNOSTIC SIGNIFICANCE OF TUMOR AND DEPTH OF ITS INVASION INTO MYOMETRIUM DIFFERENTIATION DEGREE IN ENDOMETRIAL CANCER OF INTERMEDIATE RISK
The endometrial cancer (EC) of intermediate risk includes IAG3 and IBG1—2 endometrioid carcinoma, that is, tumors with differentiation of different degrees and of the invasion into the myometrium different depths. However, the principles and methods of their management are similar. Given the difference, it is advisable to check whether IAG3 and IBG1—2 EC differ for their prognosis.
Objective. To conduct a comparative analysis of the effectiveness of treatment in terms of five-year overall, disease-free and cancer-specific survival rates of operable patients with five intrinsic molecular-biological breast cancer subtypes (T1-4N2-3M0). To establish the subtype that requires a less aggressive adjuvant systemic treatment.